On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum.

ABSTRACT: We asked if sensation-seeking is linked to premorbid personality characteristics in patients with addictive disorders, or the characteristics follow the sensation-seeking activity. We interpreted the former as a state associated with normal rates of dopamine synthesis, and the latter as a trait of individuals with abnormally high rates of synthesis. We previously determined dopaminergic receptor density in striatum, and we now tested the hypothesis that an elevated dopaminergic condition with increased extracellular dopamine and receptor density follows increased dopamine synthesis capacity in highly sensation-seeking individuals, as measured by positron emission tomography of 18 men with tracer fluorodopa (FDOPA). We detected a site in left caudate nucleus where the volume of distribution

SUBMITTER: Chang NHS 

PROVIDER: S-EPMC8825434 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature