Metabolomics-Based Frailty Biomarkers in Older Chinese Adults.

ABSTRACT:

Background/objectives

Owing to accelerated population aging, health in older adults is becoming increasingly important. Frailty can reflect the health status and disease risks of older adults; however, appropriate biomarkers for early screening of frailty have not been identified. Here, we applied metabolomics to identify frailty biomarkers and potential pathogenic mechanisms of frailty.

Methods

Serum metabolic profiles from 25 frail and 49 non-frail (control) older adults were systematically investigated by liquid chromatography-mass spectrometry-based metabolomics.

Results

We identified 349 metabolites of 46 classes, with four increased and seven decreased metabolites in frail older adults. Pearson correlation analysis identified 11 and 21 metabolites that were posi

SUBMITTER: Pan Y 

PROVIDER: S-EPMC8825494 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature