Analysis of the tumor immune environment identifies an immune gene set-based prognostic signature in non-small cell lung cancer.

ABSTRACT:

Background

The tumor immune environment plays a critical role in lung cancer initiation and prognosis. Therefore, understanding how the tumor immune environment impacts the overall survival (OS) of patients with advanced lung cancer post immunotherapy is of great importance. In this article, we aimed to identify the immune components of lung cancer and develop an immune prognostic signature to predict OS.

Methods

Differentially expressed immune-related genes were calculated between tumor and normal tissues using expression data from The Cancer Genome Atlas (TCGA) database. Then univariate Cox regression analysis was conducted to select prognosis-related genes and the prognostic risk model was constructed by multivariate Cox regression analysis. Patient risk scores were calcu

SUBMITTER: Guo G 

PROVIDER: S-EPMC8825544 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature