CircRASSF2 promotes IGF1R and osteosarcoma metastasis via sponging miR-6838-5p.

ABSTRACT:

Background

Osteosarcoma (OS) often occurs in children and adolescents and is highly malignant. Analyzing the pathogenesis of OS has great significance for prognosis and the discovery of new treatment strategies.

Methods

The effects and mechanism of circular RNA (circRNA) on OS were analyzed, as was the correlation between circRASSF2 and insulin-like growth factor 1 receptor (IGF1R) in data from The Cancer Genome Atlas (TCGA). The expression levels of microRNA (miR)-6838-5p and circRASSF2 in OS cells and osteoblasts were detected. The dual luciferase report was used to verify the targeting relationship. OS cells overexpressing circRASSF2, miR-6838-5p and/or IGF1R were constructed. The expression level of IGF1R and the biological behavior of the cells were detected. Eighty-two

SUBMITTER: Wang F 

PROVIDER: S-EPMC8825558 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature