Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies.

ABSTRACT: Diabetes is one of the most socially challenging health concerns. Even though islet transplantation has shown promise for insulin-dependent diabetes, there is still no effective method for curing diabetes due to the severe shortage of transplantable donors. In recent years, organoid technology has attracted lots of attention as organoid can mirror the human organ in vivo to the maximum extent in vitro, thus bridging the gap between cellular- and tissue/organ-level biological models. Concurrently, human pancreatic islet organoids are expected to be a considerable source of islet transplantation. To construct human islet-like organoids, the seeding cells, biomaterials and three-dimensional structure are three key elements. Herein, this review summarizes current progresses about

SUBMITTER: Jiang L 

PROVIDER: S-EPMC8825586 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature