Prognostic significance of procalcitonin in small cell lung cancer.

ABSTRACT:

Background

Procalcitonin (PCT) is a serological marker whose utility has been established in infectious disease areas. Although serum calcitonin is a prognostic predictor in patients with medullary thyroid carcinoma, the clinical usefulness of PCT remains unclear in lung cancer patients.

Methods

As a discovery cohort, we retrospectively analyzed consecutive patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) who received first-line chemotherapy at our institution, and PCT blood levels were measured. As the validation cohort, PCT blood levels were prospectively evaluated in SCLC patients before first-line chemotherapy. The correlation between a PCT increase and prognosis was examined in the discovery and validation cohorts.

Results

Twenty

SUBMITTER: Ichikawa K 

PROVIDER: S-EPMC8825657 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature