Biodistribution of Biomimetic Drug Carriers, Mononuclear Cells, and Extracellular Vesicles, in Nonhuman Primates.

ABSTRACT: Discovery of novel drug delivery systems to the brain remains a key task for successful treatment of neurodegenerative disorders. Herein, the biodistribution of immunocyte-based carriers, peripheral blood mononuclear cells (PBMCs), and monocyte-derived EVs are investigated in adult rhesus macaques using longitudinal PET/MRI imaging. ⁶⁴ Cu-labeled drug carriers are introduced via different routes of administration: intraperitoneal (IP), intravenous (IV), or intrathecal (IT) injection. Whole body PET/MRI (or PET/CT) images are acquired at 1, 24, and 48 h post injection of ⁶⁴ Cu-labeled drug carriers, and standardized uptake values (SUV_mean and SUV_max ) in the main organs are estimated. The brain retention for both types of carriers increases based

SUBMITTER: Haney MJ 

PROVIDER: S-EPMC8825682 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature