Multiple Primary Cancers in Patients Undergoing Tumor-Normal Sequencing Define Novel Associations.

ABSTRACT:

Background

Cancer survivors are developing more subsequent tumors. We sought to characterize patients with multiple (≥2) primary cancers (MPC) to assess associations and genetic mechanisms.

Methods

Patients were prospectively consented (01/2013-02/2019) to tumor-normal sequencing via a custom targeted panel (MSK-IMPACT). A subset consented to return of results of ≥76 cancer predisposition genes. International Agency for Research on Cancer (IARC) 2004 rules for defining MPC were applied. Tumor pairs were created to assess relationships between cancers. Age-adjusted, sex-specific, standardized incidence ratios (SIR) for first to second cancer event combinations were calculated using SEER rates, adjusting for confounders and time of ascertainment. Associations were made with ge

SUBMITTER: Liu YL 

PROVIDER: S-EPMC8825750 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature