Paroxetine and Mortality in Heart Failure: A Retrospective Cohort Study.

ABSTRACT:

Introduction

Paroxetine is a GRK2 inhibitor that has been widely used to treat depression and anxiety over the last few decades. The inhibition of GRK2 has been studied extensively in vivo; however, evidence of its impact on heart failure remains scarce.

Methods

To assess the association between paroxetine use and mortality in patients with heart failure. We conducted a retrospective longitudinal cohort study from 2008 to 2019, with a follow-up time of 28 days for all groups. This is a single-center study using the Medical Information Mart for Intensive Care IV database with 11,657 heart failure patients identified. We performed genetic matching to adjust for the covariates. Heart failure patients prescribed paroxetine for >24 h after hospital admission were categoriz

SUBMITTER: Xu H 

PROVIDER: S-EPMC8825765 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature