Evaluating the Diagnostic Value of a Combined Indicator of Vitamin B₁₂ Status (cB₁₂) Throughout Pregnancy.

ABSTRACT:

Background

Inadequate provision of vitamin B₁₂ during pregnancy is associated with a number of adverse maternal and fetal outcomes. We set out to (1) suggest pregnancy-specific reference ranges for a range of biomarkers of vitamin B₁₂; (2) assess the temporal behaviors of these markers over the course of pregnancy; and (3) test whether any biomarkers, including the genetic marker HIBCH rs291466 strongly associated with MMA measured early in pregnancy could reliably and significantly predict future B₁₂ status within a healthy UK population of pregnant women.

Materials and methods

We used existing biobank samples from the placebo arm of the UK Selenium in PRegnancy Intervention (SPRINT) study, to generate biochemical data for serum folat

SUBMITTER: Dib MJ 

PROVIDER: S-EPMC8825834 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature