Endotyping Seasonal Allergic Rhinitis in Children: A Cluster Analysis.

ABSTRACT:

Background

Seasonal Allergic Rhinitis (SAR) is a heterogeneous inflammatory disease. We hypothesized that a cluster analysis based on the evaluation of cytokines in nasal lavage (NL) could characterize distinctive SAR endotypes in children.

Methods

This cross-sectional study enrolled 88 children with SAR. Detailed medical history was obtained by well-trained physicians. Quality of life and sleep quality were assessed through standardized questionnaires [Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) and Pittsburgh Sleep Quality Index (PSQI) respectively]. Children were grouped through K-means clustering using Interleukin (IL)-5, IL-17, IL-23, and Interferon (INF)-γ in NL.

Results

Out of the 88 patients enrolled, 80 were included in the cluster ana

SUBMITTER: Malizia V 

PROVIDER: S-EPMC8825866 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature