Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.

ABSTRACT:

Background

Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system in which enteric ganglia are missing along a portion of the intestine. Aberrant expression of several circular RNAs (circRNAs) has been identified in the disease, but the full range of dysregulated circRNAs and their potential roles in its pathogenesis remain unclear. We used microarray profiling to systematically screen for circRNAs that were differentially expressed in HSCR, and we comprehensively analyzed the potential circRNA-miRNA-mRNA regulatory network to identify molecular mechanisms involved in the disorder.

Methods

We identified circRNAs that were differentially expressed between diseased tissue and paired normal intestinal tissues from patients with HSCR. The most st

SUBMITTER: Huang SG 

PROVIDER: S-EPMC8825940 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature