Proteomic analysis of serum proteins in children with brain death.

ABSTRACT:

Background

Brain death (BD) is a catastrophic physiological outcome that can occur in individuals with terminal illness and can adversely affect the graft quality after donation of their organs. As BD has no specific symptoms, it can be difficult to diagnose in a timely manner. The present study was designed to investigate the serum protein expression profiles of children affected by BD in an effort to define diagnostic biomarkers for this condition.

Methods

Blood samples were collected from 8 patients with BD and 8 healthy controls during the same time period. Tandem mass tags and mass spectrometry were used to conduct a proteomic analysis of serum extracted from the samples. The potential regulatory roles of the top 5 upregulated and downregulated proteins identified throu

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8825943 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature