RCSB Protein Data Bank: improved annotation, search and visualization of membrane protein structures archived in the PDB.

ABSTRACT:

Motivation

Membrane proteins are encoded by approximately one fifth of human genes but account for more than half of all US FDA approved drug targets. Thanks to new technological advances, the number of membrane proteins archived in the PDB is growing rapidly. However, automatic identification of membrane proteins or inference of membrane location is not a trivial task.

Results

We present recent improvements to the RCSB Protein Data Bank web portal (RCSB PDB, rcsb.org) that provide a wealth of new membrane protein annotations integrated from four external resources: OPM, PDBTM, MemProtMD and mpstruc. We have substantially enhanced the presentation of data on membrane proteins. The number of membrane proteins with annotations available on rcsb.org was increased by ∼80%. Users

SUBMITTER: Bittrich S 

PROVIDER: S-EPMC8826025 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature