Association of Angiogenesis Gene Expression With Cancer Prognosis and Immunotherapy Efficacy.

ABSTRACT: Background: Several new blood vessels are formed during the process of tumor development. These new blood vessels provide nutrients and water for tumour growth, while spreading tumour cells to distant areas and forming new metastases in different parts of the body. The available evidence suggests that tumour angiogenesis is closely associated with the tumour microenvironment and is regulated by a variety of pro-angiogenic factors and/or angiogenic inhibitors. Methods: In the present study, a comprehensive characterization of angiogenesis genes expression was performed in a pan-cancer analysis across the 33 human cancer types. Further, genetic data from several public databases were also used in the current study. An angiogenesis score was assigned to The Cancer Genome Atlas (

SUBMITTER: Li XY 

PROVIDER: S-EPMC8826089 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature