Association of the Gut Microbiota With Cognitive Function in Midlife.

ABSTRACT:

Importance

Animal experiments and small clinical studies support a role for the gut microbiota in cognitive functioning. Few studies have investigated gut microbiota and cognition in large community samples.

Objective

To examine associations of gut microbial composition with measures of cognition in an established population-based study of middle-aged adults.

Design, setting, and participants

This cross-sectional study analyzed data from the prospective Coronary Artery Risk Development in Young Adults (CARDIA) cohort in 4 US metropolitan centers between 2015 and 2016. Data were analyzed in 2019 and 2020.

Exposures

Stool DNA were sequenced, and the following gut microbial measures were gathered: (1) β-diversity (between-person) derived with multivariate principa

SUBMITTER: Meyer K 

PROVIDER: S-EPMC8826173 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature