Melatonin, Zinc, and Vitamin C: Potential Adjuvant Treatment for COVID-19 Patients.

ABSTRACT: The use of nutraceutical approaches may regulate the immune system, performing a potential strategy to contain the worst outcomes of COVID-19. We reviewed the current evidence surrounding nutritional/nutraceutical approaches for the therapy in patients with COVID-19. We searched the PubMed database to report randomized controlled trials (RCTs) and observational research that used melatonin, zinc, or vitamin C supplementation as an intervention for COVID-19 treatment. To date, we found only three concluded studies that assessed zinc supplementation and melatonin therapy in patients with COVID-19, but with inconclusive data, relatively small sample size, and early termination of the trial. On the other hand, vitamin C therapy appears to reduce hyperinflammation and improve the oxygen support

SUBMITTER: Borges L 

PROVIDER: S-EPMC8826215 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature