Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample.

ABSTRACT:

Background

Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent.

Objective

To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies.

Methods

The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction.

Results

The meta-ana

SUBMITTER: Wen K 

PROVIDER: S-EPMC8826222 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature