Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study.

ABSTRACT:

Objective

The aim of this exploratory study was to investigate the development of low-grade inflammation during ageing and its relationship with frailty.

Methods

The trajectories of 18 inflammatory markers measured in blood samples, collected at 5-year intervals over a period of 20 years from 144 individuals aged 65-75 years at the study endpoint, were related to the degree of frailty later in life.

Results

IFN-γ-related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL-6 pathway markers, such as CRP and sIL-6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in wome

SUBMITTER: Samson LD 

PROVIDER: S-EPMC8826353 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature