A Novel Immunobiotics Bacteroides dorei Ameliorates Influenza Virus Infection in Mice.

ABSTRACT:

Objective

Probiotics can modulate immune responses to resist influenza infection. This study aims to evaluate the anti-viral efficacy of B. dorei.

Methods

C57BL/6J mice were infected with influenza virus together with treatment of PBS vehicle, B. dorei, or oseltamivir respectively. Anti-influenza potency of B. dorei and the underlying mechanism were determined by measuring survival rate, lung viral load and pathology, gene expression and production of cytokines and chemokines, and analysis of gut microbiota.

Results

Administration of B. dorei increased (by 30%) the survival of influenza-infected mice, and improved their weight loss, lung pathology, lung index, and colon length compared to the vehicle control group. B. dorei treatment

SUBMITTER: Song L 

PROVIDER: S-EPMC8826429 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature