Brain Morphometry and Cognitive Performance in Normal Brain Aging: Age- and Sex-Related Structural and Functional Changes.

ABSTRACT:

Background

The human brain structure undergoes considerable changes throughout life. Cognitive function can be affected either negatively or positively. It is challenging to segregate normal brain aging from the accelerated one.

Objective

To work out a descriptive model of brain structural and functional changes in normal aging.

Materials and methods

By using voxel-based morphometry and lesion segmentation along with linear statistics and machine learning (ML), we analyzed the structural changes in the major brain compartments and modeled the dynamics of neurofunctional performance throughout life. We studied sex differences in lifelong dynamics of brain volumetric data with Mann-Whitney U-test. We tested the hypothesis that performance in some cognitive domain

SUBMITTER: Statsenko Y 

PROVIDER: S-EPMC8826453 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature