Association of Genetic Testing Results With Mortality Among Women With Breast Cancer or Ovarian Cancer.

ABSTRACT:

Background

Breast cancer and ovarian cancer patients increasingly undergo germline genetic testing. However, little is known about cancer-specific mortality among carriers of a pathogenic variant (PV) in BRCA1/2 or other genes in a population-based setting.

Methods

Georgia and California Surveillance Epidemiology and End Results (SEER) registry records were linked to clinical genetic testing results. Women were included who had stages I-IV breast cancer or ovarian cancer diagnosed in 2013-2017, received chemotherapy, and were linked to genetic testing results. Multivariable Cox proportional hazard models were used to examine the association of genetic results with cancer-specific mortality.

Results

22 495 breast cancer and 4320 ovarian cancer patients were analyzed, w

SUBMITTER: Kurian AW 

PROVIDER: S-EPMC8826508 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature