A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes.

ABSTRACT:

Background

Pancreatic cancer (PC) has a grim prognosis, and an early diagnostic biomarker has been highly desired. The molecular link between diabetes and PC has not been well established.

Methods

Bioinformatics screening was performed for a serum PC marker. Experiments in cell lines (5 PC and 1 normal cell lines), mouse models, and human tissue staining (37 PC and 10 normal cases) were performed to test asprosin production from PC. Asprosin's diagnostic performance was tested with serums from multi-center cohorts (347 PC, 209 normal, and 55 additional diabetic patients) and evaluated according to PC status, stages, and diabetic status, which was compared with that of CA19-9.

Results

Asprosin, a diabetes-related hormone, was found from the bioinformatics screening, an

SUBMITTER: Nam H 

PROVIDER: S-EPMC8826585 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature