Metabolomic basis for response to high dose vitamin D in critical illness.

ABSTRACT:

Background & aims

It is unclear if intervention can mitigate the dramatic alterations of metabolic homeostasis present in critical illness. Our objective was to determine the associations between increased 25-hydroxyvitamin D levels following high dose vitamin D₃ and more favorable metabolomic profiles in critical illness.

Methods

We performed a post-hoc metabolomics study of the VITdAL-ICU randomized double-blind, placebo-controlled trial. Trial patients from Medical and Surgical Intensive Care Units at a tertiary university hospital with 25-hydroxyvitamin D level ≤20 ng/mL received either high dose oral vitamin D₃ (540,000 IU) or placebo. We performed an analysis of 578 metabolites from 1215 plasma samples from 428 subjects at randomization (day 0), d

SUBMITTER: Amrein K 

PROVIDER: S-EPMC8826589 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature