Antischistosomal tetrahydro-γ-carboline sulfonamides.

ABSTRACT: We discovered tetrahydro-γ-carboline sulfonamides as a new antischistosomal chemotype. The aryl sulfonamide and tetrahydro-γ-carboline substructures were required for high antischistosomal activity. Increasing polarity improved solubility and metabolic stability but decreased antischistosomal activity. We identified two compounds with IC₅₀ values <5 µM against ex vivo Schistosoma mansoni.

SUBMITTER: Ren R 

PROVIDER: S-EPMC8826590 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature