Clinical Implications of Inter- and Intratumor Heterogeneity of Immune Cell Markers in Lung Cancer.

ABSTRACT:

Background

Immune cell transcriptome signatures have been widely used to study the lung tumor microenvironment (TME). However, it is unclear to what extent the immune cell composition in the lung TME varies across histological and molecular subtypes (intertumor heterogeneity [inter-TH]) and within tumors (intratumor heterogeneity [ITH]) and whether ITH has any prognostic relevance.

Methods

Using RNA sequencing in 269 tumor samples from 160 lung cancer patients, we quantified the inter-TH of immune gene expression and immune cell abundance and evaluated the association of median immune cell abundance with clinical and pathological features and overall survival. In 39 tumors with 132 multiregion samples, we also analyzed the ITH of immune cell abundance in relation to overall

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8826638 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature