Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.

ABSTRACT:

Background

Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING), is a rare clinical entity with an unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes mellitus or other predisposing diagnoses. To achieve insights into its pathogenesis, we queried the clinical, histopathologic and transcriptomic features of ING and nodular diabetic nephropathy (DN).

Methods

All renal biopsy reports accessioned at Indiana University Health from 2001 to 2016 were reviewed to identify 48 ING cases. Clinical and histopathologic features were compared between individuals with ING and DN (n = 751). Glomeruli of ING (n = 5), DN (n = 18) and reference (REF) nephr

SUBMITTER: Eadon MT 

PROVIDER: S-EPMC8826640 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature