The association between interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Introduction

It is reported that there is a close association between interleukin-1β (IL-1β) gene polymorphisms and breast cancer risk. However, the results remain controversial.

Material and methods

Eligible published articles were searched in PubMed, Embase, and Web of Science databases up to June 2018. Odds ratios with 95% confidence intervals were used to identify potential links between IL-1β genetic polymorphisms and the risk of breast cancer.

Results

From our results, we found that three common polymorphisms in IL-1β (rs16944, rs1143634, rs1143627) had no significant associations with breast cancer risk in all genetic models. Based on the analysis from ethnic subgroups, there was a higher risk of breast cancer for rs16944 polymorphism in the recessive model and

SUBMITTER: Wang B 

PROVIDER: S-EPMC8826693 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature