Axillary Microbiota Is Associated with Cognitive Impairment in Parkinson's Disease Patients.

ABSTRACT: Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high interindividual variability, which requires better diagnostic and monitoring strategies. PD patients often display sweating disorders resulting from autonomic dysfunction, which has been associated with CI. Because the axillary microbiota is known to change with humidity level and sweat composition, we hypothesized that the axillary microbiota of PD patients shifts in association with CI progression, and thus can be used as a proxy for classification of CI stages in PD. We compared the axillary microbiota compositions of 103 PD patients (55 PD patients with dementia [PDD

SUBMITTER: Arikan M 

PROVIDER: S-EPMC8826741 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature