Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma.

ABSTRACT:

Background

Many factors impact survival in patients with glioblastoma, including age, Karnofsky Performance Status, postoperative chemoradiation, IDH1/2 mutation status, MGMT promoter methylation status, and extent of resection. High-throughput next-generation sequencing is a widely available diagnostic tool, but the independent impact of tumors harboring specific mutant genes on survival and the efficacy of extent of resection are not clear.

Methods

We utilized a widely available diagnostic platform (FoundationOne CDx) to perform high-throughput next-generation sequencing on 185 patients with newly diagnosed glioblastoma in our tertiary care center. We performed multivariate analysis to control for clinical parameters with known impact on survival to elucidate

SUBMITTER: Yang PH 

PROVIDER: S-EPMC8826782 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature