Economically Efficient Hepatitis C Virus Treatment Prioritization Improves Health Outcomes.

ABSTRACT:

Background

The total cost of treating the 3 million Americans chronically infected with hepatitis C virus (HCV) represents a substantial affordability challenge requiring treatment prioritization. This study compares the health and economic outcomes of alternative treatment prioritization schedules.

Methods

We developed a multiyear HCV treatment budget allocation model to evaluate the tradeoffs of 7 prioritization strategies. We used optimization to identify the priority schedule that maximizes population net monetary benefit (NMB). We compared prioritization schedules in terms of the number of individuals treated, the number of individuals who progress to end-stage liver disease (ESLD), and population total quality-adjusted life years (QALYs). We applied the model to the po

SUBMITTER: Cipriano LE 

PROVIDER: S-EPMC8826843 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature