Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants.

ABSTRACT: SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted global attention due to its significant resistance to current antibody therapies and vaccines. Here, we profiled the mutations of Omicron and other various circulating SARS-CoV-2 variants in parallel by computational interface analysis and in vitro experimental assays. We identified critical mutations that lead to antigenicity changes and diminished neutralization efficiency of a panel of 14 antibodies due to diverse molecular mechanisms influencing the antigen-antibody interaction. Our study identified that Omicron exhibited extraordinary potency in immune escape compared to the other variants of concern, and explores

SUBMITTER: Sun C 

PROVIDER: S-EPMC8826850 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature