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Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.

ABSTRACT: Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of blood molecules by four features: (i) the decomposability into "amplitude" and "rate" components, (ii) the similarity of temporal patterns among individuals, (iii) the relation of molecules over time among individuals, and (iv) the similarity of temporal patterns among molecules. Glucose and glucose metabolism-related hormones indicated a rapid increase, and citrulline and lipids, which indicated a rapid decrease, returned to fasting levels faster than amino acids. Compared to glucose metabolism-related molecules and lipids, amino acids showed similar temporal patterns among individuals. The four features of temporal patterns of blood molecules by oral glucose ingestion characterize the differences among individuals and among molecules.

SUBMITTER: Fujita S

PROVIDER: S-EPMC8826934 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.

Fujita Suguru S Karasawa Yasuaki Y Fujii Masashi M Hironaka Ken-Ichi KI Uda Shinsuke S Kubota Hiroyuki H Inoue Hiroshi H Sumitomo Yohei Y Hirayama Akiyoshi A Soga Tomoyoshi T Kuroda Shinya S

NPJ systems biology and applications 20220208 1

Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of ...[more]

PMID: 35136093

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Dataset Information

Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.

Publications

Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.

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