Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics.
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ABSTRACT:
SUBMITTER: Konar M
PROVIDER: S-EPMC8827053 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics.
Konar Mouli M Ghosh Debasis D Samanta Sourav S Govindaraju Thimmaiah T
RSC chemical biology 20211223 2
Amyloid beta (Aβ) aggregation species-associated cellular stress instigates cytotoxicity and adverse cellular stiffness in neuronal cells. The study and modulation of these adverse effects demand immediate attention to tackle Alzheimer's disease (AD). We present a <i>de novo</i> design, synthesis and evaluation of Aβ14-23 peptidomimetics with cyclic dipeptide (CDP) units at defined positions. Our study identified Akd<sup>NMC</sup> with CDP units at the middle, N- and C-termini as a potent candid ...[more]
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