A proinflammatory diet is associated with increased odds of frailty after 12-year follow-up in a cohort of adults.

ABSTRACT:

Background

Frailty occurs in 10-15% of community-living older adults and inflammation is a key determinant of frailty. Though diet is a modulator of inflammation, there are few prospective studies elucidating the role of diet-associated inflammation on frailty onset.

Objectives

We sought to determine whether a proinflammatory diet was associated with increased odds of frailty in adults from the Framingham Heart Study (FHS).

Design and methods

This study was nested in a prospective cohort that included individuals without frailty. Diet was assessed in 1998-2001 using a valid FFQ, and frailty was measured in 2011-2014. FFQ-derived energy-adjusted dietary inflammatory index (E-DII®) scores were computed, with higher E-DII scores indicating a more proinflammatory diet. Fr

SUBMITTER: Millar CL 

PROVIDER: S-EPMC8827080 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature