Maternal caffeine intake and DNA methylation in newborn cord blood.

ABSTRACT:

Background

Epigenetic mechanisms may underlie associations between maternal caffeine consumption and adverse childhood metabolic outcomes. However, limited studies have examined neonate DNA methylation (DNAm) patterns in the context of preconception or prenatal exposure to caffeine metabolites.

Objectives

We examined preconception and pregnancy caffeine exposure with DNAm alterations in neonate cord blood (n = 378).

Methods

In a secondary analysis of the Effects of Aspirin in Gestation and Reproduction Trial (EAGeR), we measured maternal caffeine, paraxanthine, and theobromine concentrations from stored serum collected preconception (on average 2 months before pregnancy) and at 8 weeks of gestation. In parallel, self-reported caffeinated beverage intake was captured v

SUBMITTER: Polinski KJ 

PROVIDER: S-EPMC8827095 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature