DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m⁶A/DDIT4/PGC1α signaling.

ABSTRACT:

Background

Obesity leads to a decline in the exercise capacity of skeletal muscle, thereby reducing mobility and promoting obesity-associated health risks. Dietary intervention has been shown to be an important measure to regulate skeletal muscle function, and previous studies have demonstrated the beneficial effects of docosahexaenoic acid (DHA; 22:6 ω-3) on skeletal muscle function. At the molecular level, DHA and its metabolites were shown to be extensively involved in regulating epigenetic modifications, including DNA methylation, histone modifications, and small non-coding microRNAs. However, whether and how epigenetic modification of mRNA such as N6-methyladenosine (m6A) mediates DHA regulation of skeletal muscle function remains unknown. Here, we analyze the regulatory effec

SUBMITTER: Chen W 

PROVIDER: S-EPMC8827147 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature