Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes.

ABSTRACT:

Background

Most of the known genes required for developmental processes have been identified by genetic screens in a few well-studied model organisms, which have been considered representative of related species, and informative-to some degree-for human biology. The fruit fly Drosophila melanogaster is a prime model for insect genetics, and while conservation of many gene functions has been observed among bilaterian animals, a plethora of data show evolutionary divergence of gene function among more closely-related groups, such as within the insects. A quantification of conservation versus divergence of gene functions has been missing, without which it is unclear how representative data from model systems actually are.

Results

Here, we systematically compare the gene sets re

SUBMITTER: Hakeemi MS 

PROVIDER: S-EPMC8827203 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature