Enhanced intestinal protein fermentation in schizophrenia.

ABSTRACT:

Background

Emerging findings highlighted the associations of mental illness to nutrition and dysbiosis in the intestinal microbiota, but the underlying mechanisms, especially in schizophrenia (SZ), remain unclarified.

Methods

We conducted a case-control study of SZ patients (case to control=100:52) by performing sequencing of the gut metagenome; measurement of fecal and plasma non-targeted metabolome; including short-, medium-, and long-chain fatty acids; and targeted metabolites, along with recorded details of daily intakes of food.

Results

The metagenome analysis uncovered enrichment of asaccharolytic species and reduced abundance of carbohydrate catabolism pathways and enzymes in the gut of SZ patients, but increased abundance of peptidases in contrast to their sig

SUBMITTER: Liang Y 

PROVIDER: S-EPMC8827269 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature