Identification of the Expression and Clinical Significance of E2F Family in Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Background

Multiple studies have identified that E2F transcriptions act as important regulators for the tumorigenesis and progression of several human cancers. However, little is known about the function of E2Fs in clear cell renal cell carcinoma (ccRCC).

Methods

We firstly investigated the expression levels, genetic alteration, and biological function of E2Fs in patients with ccRCC and the connections between the immune cell infiltration and the overall survivals of ccRCC patients with the E2Fs expression levels based on UALCAN, The Cancer Genome Atlas database, Gene Expression Profiling Interactive Analysis, TIMER, STRING, GSCALite and cBioPortal databases.

Results

Results revealed that the expression levels of E2F1/2/3/4/6/7/8 were markedly upregulated in patients

SUBMITTER: Chen R 

PROVIDER: S-EPMC8827415 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature