Programme death ligand 1 expressions as a surrogate for determining immunotherapy in cervical carcinoma patients.

ABSTRACT:

Background

The programme death ligand1 and its receptor (PD-1/PD-L1) interaction is a target for blockage by immunotherapy that uses the body's own immune system. Some studies show that PD-L1 expressing tumours are also more aggressive with poor prognosis. This study evaluated the immunohistochemical expression of PD-L1 in uterine cervical carcinomas. Women with cervical cancer would benefit from its use as a marker in therapy and prognosis.

Methods

Hospital-based cross-sectional retrospective study was conducted. The study materials included 183 archived formalin fixed and paraffin embedded (FFPE) tissue blocks with histological diagnosis of cervical carcinoma diagnosed in our facility within a five-year period (January 2012 and December 2016) that met the study criteria. D

SUBMITTER: Omenai SA 

PROVIDER: S-EPMC8827435 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature