Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial.

ABSTRACT:

Introduction

Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our aim is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) for prophylaxis of coronavirus disease 19 (COVID-19) in health personnel exposed to patients infected by SARS-CoV-2.

Methods

Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were health care workers caring for severe COVID-19 patients. Main outcome was time to symptomatic SARS-CoV-2 infection.

Results

127 subjects with a confirmed baseline negative RT-PCR SARS-CoV2 test were included in the trial. 62 assigned to HCQ and 65 to placebo. One subject (1.6%) in the HCQ group and 6 (9.2%) subjects in the placebo group dev

SUBMITTER: Rojas-Serrano J 

PROVIDER: S-EPMC8827445 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature