Traveling wave of inflammatory response to regulate the expansion or shrinkage of skin erythema.

ABSTRACT: Many skin diseases show circular red lesions on the skin, called erythema. Erythema is characterized by the expansion of its circular area solely from local stimulation. A pathological inflammatory response caused by the stimulation persistently increases inflammatory mediators in the dermis, whereas a normal inflammatory response transiently increases mediators, resulting in the shrinkage of the erythema. Although the diffusion of mediators theoretically reproduces the expansion, how the inflammatory response expands or shrinks the erythema remains unknown. A possibility is positive feedback, which affects mediator production and can generate two distinct stable states (i.e., inflamed and noninflamed), referred to as bistability. Bistability causes a state transition either from the nonin

SUBMITTER: Sudo M 

PROVIDER: S-EPMC8827459 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature