Pyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons.

ABSTRACT: Corticostriatal connectivity is central for many cognitive and motor processes, such as reinforcement or action initiation and invigoration. The cortical input to the striatum arises from two main cortical populations: intratelencephalic (IT) and pyramidal tract (PT) neurons. We report a previously unknown excitatory circuit, supported by a polysynaptic motif from PT neurons to cholinergic interneurons (ChIs) to glutamate-releasing axons, which runs in parallel to the canonical monosynaptic corticostriatal connection. This motif conveys a delayed second phase of excitation to striatal spiny projection neurons, through an acetylcholine-dependent glutamate release mechanism mediated by α4-containing nicotinic receptors, resulting in biphasic corticostriatal signals. These biphasic signals ar

SUBMITTER: Morgenstern NA 

PROVIDER: S-EPMC8827762 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature