KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.

ABSTRACT: Dynamic microtubules play a critical role in cell structure and function. In nervous system, microtubules are the major route for cargo protein trafficking and they specially extend into and out of synapses to regulate synaptic development and plasticity. However, the detailed depolymerization mechanism that regulates dynamic microtubules in synapses and dendrites is still unclear. In this study, we find that KIF2C, a dynamic microtubule depolymerization protein without known function in the nervous system, plays a pivotal role in the structural and functional plasticity of synapses and regulates cognitive function in mice. Through its microtubule depolymerization capability, KIF2C regulates microtubule dynamics in dendrites, and regulates microtubule invasion of spines in neurons in a neu

SUBMITTER: Zheng R 

PROVIDER: S-EPMC8828051 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature