Heparinized swine models for better surgical/endoscopic training.

ABSTRACT:

Introduction

Animal experiments with large living animals are essential for the development of medical devices and the training of surgical procedures. Swine are frequently used in animal experiments due to their similar size and anatomy compared to humans. However, it is well known that swine has less local bleeding than humans. The aim of the study was to verify whether animal models with appropriate local bleeding capability could be established.

Methods

The activated clotting time (ACT) was measured for eight swine (piglet, 35 kg) under general anesthesia. The flexible endoscope was advanced orally, and the gastric mucosa was intentionally traumatized to bleed by biopsy forceps, and the time until spontaneous hemostasis was obtained (mucosal bleeding time). Then, heparin

SUBMITTER: Kubo Y 

PROVIDER: S-EPMC8828249 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature