Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.

ABSTRACT: Research into the prevention and treatment of age-related metabolic diseases are important in the present-day situation of the aging population. We propose that an elderly diabetic mouse model may be useful to such research as it exhibits deterioration of glucose and lipid metabolism. Although the KK mouse strain is commonly used as a model of moderate obesity and type 2 diabetes, the utility of this strain as an elderly obese and diabetic model mouse for research into aging remains unclear. The present study aimed to investigate age-related changes of glucose and lipid metabolism in male KK mice fed a standard chow diet. We demonstrate that 40 weeks KK mice exhibit age-related dysfunctions, such as development of insulin resistance associated with pancreatic islet hypertrophy and decrease

SUBMITTER: Iizuka Y 

PROVIDER: S-EPMC8828408 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature