Dataset Information

Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID).

ABSTRACT:

Background

The COVID-19 pandemic caused major oncology care pathway disruption. The CAPANCOVID study aimed to evaluate the impact on pancreatic adenocarcinoma (PA) - from diagnosis to treatment - of the reorganisation of the health care system during the first lockdown.

Methods

This multicentre ambispective observational study included 833 patients diagnosed with PA between September 1, 2019 and October 31, 2020 from 13 French centres. Data were compared over three periods defined as before the outbreak of COVID-19, during the first lockdown (March 1 to May 11, 2020) and after lockdown.

Results

During the lockdown, mean weekly number of new cases decreased compared with that of pre-pandemic levels (13.2 vs. 10.8, -18.2%; p = 0.63) without rebound in the post-lockdown period (13.2 vs. 12.9, -1.7%; p = 0.97). The number of borderline tumours increased (13.6%-21.7%), whereas the rate of metastatic diseases rate dropped (47.1%-40.3%) (p = 0.046). Time-to-diagnosis and -treatment were not different over periods. Waiting neoadjuvant chemotherapy in resectable tumours was significantly favoured (24.7%-32.6%) compared with upfront surgery (13%-7.8%) (p = 0.013). The use of mFOLFIRINOX preoperative chemotherapy regimen decreased (84.9%-69%; p = 0.044). After lockdown, the number of borderline tumours decreased (21.7%-9.6%) and advanced diseases increased (59.7%-69.8%) (p = 0.046). SARS-CoV-2 infected 39 patients (4.7%) causing 5 deaths (12.8%).

Conclusion

This cohort study suggests the existence of missing diagnoses and of a shift in disease stage at diagnosis from resectable to advanced diseases with related therapeutic modifications whose prognostic consequences will be known after the planned follow-up.

Trial registration

Clinicaltrials.gov NCT04406571.

SUBMITTER: Brugel M

PROVIDER: S-EPMC8828421 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID).

Brugel Mathias M Letrillart Léa L Evrard Camille C Thierry Aurore A Tougeron David D El Amrani Mehdi M Piessen Guillaume G Truant Stéphanie S Turpin Anthony A d'Engremont Christelle C Roth Gaël G Hautefeuille Vincent V Regimbeau Jean M JM Williet Nicolas N Schwarz Lilian L Di Fiore Frédéric F Borg Christophe C Doussot Alexandre A Lambert Aurélien A Moulin Valérie V Trelohan Hélène H Bolliet Marion M Topolscki Amalia A Ayav Ahmet A Lopez Anthony A Botsen Damien D Piardi Tulio T Carlier Claire C Bouché Olivier O

European journal of cancer (Oxford, England : 1990) 20220210

<h4>Background</h4>The COVID-19 pandemic caused major oncology care pathway disruption. The CAPANCOVID study aimed to evaluate the impact on pancreatic adenocarcinoma (PA) - from diagnosis to treatment - of the reorganisation of the health care system during the first lockdown.<h4>Methods</h4>This multicentre ambispective observational study included 833 patients diagnosed with PA between September 1, 2019 and October 31, 2020 from 13 French centres. Data were compared over three periods defined ...[more]

PMID: 35259629

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Dataset Information

Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID).

Background

Methods

Results

Conclusion

Trial registration

Publications

Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID).

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