Broadly neutralizing antibodies target a haemagglutinin anchor epitope.

ABSTRACT: Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection¹. However, viral mutants that escape broadly neutralizing antibodies have been reported^2,3. The identification of broadly neutralizing antibody classes that can neutralize viral escape mutants is critical for universal influenza virus vaccine design. Here we report a distinct class of broadly neutralizing antibodies that target a discrete membrane-proximal anchor epitope of the haemagglutinin stalk domain. Anchor epitope-targeting antibodies are broadly neutralizing across H1 viruses and can cross-react with H2 and H5 viruses that are a pandemic threat. Antibodies that target this anchor

SUBMITTER: Guthmiller JJ 

PROVIDER: S-EPMC8828479 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature