Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma.

ABSTRACT:

Background

The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. However, we do not know how this is propagated to the offspring.

Objectives

We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma.

Methods

We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming.

Results

The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effe

SUBMITTER: Furse S 

PROVIDER: S-EPMC8828597 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature